Quinolines and derivatives

Medchemexpress LLC Sulfur, [3-cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]... | 1448316-08-2 | 99.9% | 558.53 g·mol⁻¹ | C26H19F5N6OS | 1 ML

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BAY-826 is a selective, potent small-molecule inhibitor of the TIE-2 kinase supplied for research use. It binds TIE-2 with high affinity (Kd ≈ 1.6 nM) and is provided as a 10 mM solution in DMSO (1 mL) or as solid quantities. Typical applications include biochemical kinase assays and cell-based studies of angiogenesis signaling pathways.

• Selective TIE-2 inhibition with Kd ≈ 1.6 nM.
• Available as 10 mM solution in DMSO (1 mL) and multiple solid sizes.
• High purity suitable for research applications.
• Molecular formula C26H19F5N6OS; molecular weight 558.53 g·mol⁻1.
• Soluble in DMSO for convenient assay preparation.
• Suitable for biochemical and cell-based assays targeting TIE-2 signaling.

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Medchemexpress LLC Veliparib | 912444-00-9 | MFCD16661059 | 244.29 g/mol | C13H16N4O | 200 MG

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Veliparib (ABT-888) is a small-molecule inhibitor of poly(ADP-ribose) polymerases used in research to probe DNA repair pathways and for chemosensitization studies. It is supplied as a solid for analytical and preclinical research and has documented storage recommendations for powder and solutions.

• Potent PARP1 and PARP2 inhibition (Ki 5.2 nM and 2.9 nM).
• Molecular formula C13H16N4O and molecular weight 244.29 g/mol.
• Identified by CAS number 912444-00-9.
• Supplied as a powder with recommended storage: -20°C (3 years) or 4°C (2 years).
• Stable in solvent when stored at -80°C (1 year) or -20°C (6 months).

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Selleck Chemical LLC Q-VD-Oph

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Q-VD-Oph (Quinoline-Val-Asp-Difluorophenoxymethylketone) is a potent pan-caspase inhibitor with IC50 ranged from 25 to 400 nM for caspases 1 3 8 and 9 Q-VD-OPh can inhibits HIV infection

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Apexbio Technology LLC Oxymatrine 16837-52-8 200mg

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Oxymatrine (CAS 16837-52-8) is a quinolizidine alkaloid extracted from Sophora flavescens It has been shown to modulate multiple cellular pathways associated with fibrosis and neurodegeneration including inhibition of TGF- 1-mediated signaling and reduction of pro-inflammatory cytokine expression Oxymatrine exhibits antifibrotic and neuroprotective properties in various experimental models It is also extensively studied for its antiviral activity against hepatitis B virus and has been applied in traditional Chinese medicine for hepatitis management This compound is valuable for investigating mechanisms of fibrosis neuroprotection and viral pathogenesis

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Apexbio Technology LLC Emodin 518-82-1 200mg

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Emodin (518-82-1) is a small-molecule inhibitor targeting casein kinase 2 (CK2) and the interaction between SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) It is designed to block protein protein interactions and enzyme activity thereby modulating viral entry and kinase-mediated signaling Emodin exerts its biological activity primarily through inhibition of CK2 and disruption of spike ACE2 binding In hepatocellular carcinoma cell models (Hep3B HepG2 Huh7) emodin demonstrates antiproliferative activity with IC50 values of 66 9 M in Hep3B 74 36 M in HepG2 and 101 5 M in Huh7 cells Based on these pharmacological properties emodin holds research potential in cancer inflammation metabolic disorders and viral infection models

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Medchemexpress LLC 3,7,4'-Trihydroxyflavone | 2034-65-3 | 99.4% | 270.24 | 1 ML

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3,7,4'-Trihydroxyflavone, also known as 5-Deoxykampferol, is a flavonoid compound isolated from the stems of Rhus javanica var. roxburghiana. It exhibits anti-inflammatory and antioxidant properties by scavenging various reactive oxygen species (ROS) and reactive nitrogen species (RNS), and can also cleave DNA in the presence of copper ions.

• Isolated from natural sources like Rhus javanica var. roxburghiana.
• Functions as an anti-inflammatory agent.
• Possesses antioxidant activities.
• Capable of scavenging reactive oxygen and nitrogen species.
• Can cleave DNA when copper ions are present.